Band 3/AE1/SLC4A1抗体

产品货号：

Z11581

中文名称：

Band 3/AE1/SLC4A1抗体

英文名称：

Anti-Band 3/AE1/SLC4A1 Antibody

产品规格：

50μl|100μl|150μl

发货周期：

1～3天

产品价格：

询价

抗体名称	Anti-Band 3/AE1/SLC4A1 Antibody
指标别名	AE 1;AE1;Anion exchange protein 1;Anion exchanger 1;band 3;Band 3 anion transport protein;band 3/AE1;CD233;SLC4A1
克隆性	Polyclonal
检验物种	human,mouse,rat
应用范围	WB,IHC,IHC-F,IF,FCM
基因名称	SLC4A1
抗体来源	Rabbit
抗体类型	IgG
免疫原	E.coli-derived human Band 3 (Position:E28-N365).Human Band 3 shares 75.7% and 74.5% amino acid (aa) sequence identity with mouse and rat Band 3,respectively.
实际分子量	102KD
成分	500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式	Immunogen affinity purified.
浓度	500μg/mL
产品形态	溶液
保存条件	12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料	Band 3 is also known as SLC4A1.The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane,where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs.The protein comprises two domains that are structurally and functionally distinct.The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin.The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions.The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II.The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger.This protein is predominantly dimeric but forms tetramers in the presence of ankyrin.Many mutations in this gene are known in man,and these mutations can lead to two types of disease:destabilization of red cell membrane leading to hereditary spherocytosis,and defective kidney acid secretion leading to distal renal tubular acidosis.Other mutations that do not give rise to disease result in novel blood group antigens,which form the Diego blood group system.
Uniprot ID	P02730
推荐配套试剂	Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。
基因名全称	solute carrier family 4 (anion exchanger),member 1 (Diego blood group)
蛋白名全称	Band 3 anion transport protein
推荐稀释比	Western blot(WB) 1:500～2000 Flow cytometry (FCM) 1～3μg/1×10⁶ cells Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunofluorescence (IF) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user.

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